Last updated July 22, 2026
Key finding
BoP was reduced in the intervention group to approximately 5.5% more than the control group.
This study evaluated the efficacy of hyaluronic acid in non-surgical periodontal treatment for patients with type 2 diabetes, finding it reduced bleeding on probing and clinical attachment levels compared to a placebo.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the efficacy of hyaluronic acid in non-surgical periodontal treatment for patients with type 2 diabetes, finding it reduced bleeding on probing and clinical attachment levels compared to a placebo.
These findings suggest that hyaluronic acid may be a beneficial adjunct in periodontal therapy for patients with type 2 diabetes, potentially improving oral health outcomes. Given the prevalence of periodontal disease in diabetic patients, effective treatments are crucial for managing their overall health.
Non-randomized design may introduce bias. Sample size and demographic details not specified. Short follow-up period limits long-term effectiveness conclusions.
Published in
Publication details and source links for this paper.
Iwona O, Ewa M, Agata D, Irina-Georgeta S, Sorina MS. Efficacy of Hyaluronic Acid in Non-Surgical Periodontal Treatment for Patients with Type 2 Diabetes. Biomedicines. 2024;12(11):2516. doi:10.3390/biomedicines12112516
Bleeding on probing was reduced by 5.5% in the hyaluronic acid group (p=0.001).
Clinical attachment level decreased by 1 mm more in the hyaluronic acid group than in the control (p<0.001).
No significant difference in probing depth between groups.
Glycated hemoglobin levels showed no significant difference after treatment.
Evidence network
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This study contributes evidence to Hyaluronic Acid Application and Bleeding on probing, Clinical attachment level, HbA1c, and 1 more.
This study contributes evidence to
Primary intervention
Hyaluronic Acid Application
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
4
Evidence pairs
310
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Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Hyaluronic Acid Application → Bleeding on probing
Hyaluronic Acid Application → Bleeding on probing
Hyaluronic Acid Application → Clinical attachment level
Hyaluronic Acid Application → Clinical attachment level
Hyaluronic Acid Application → Periodontal probing depth
Hyaluronic Acid Application → Periodontal probing depth
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Hyaluronic Acid Application and Bleeding on probing, Hyaluronic Acid Application and Clinical attachment level.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Bleeding on probing
Measures Bleeding on probing as a key outcome.
All studies measuring Clinical attachment level
Measures Clinical attachment level as a key outcome.
All studies on Hyaluronic Acid Application
Contributes to Hyaluronic Acid Application evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Hyaluronic Acid Application appears to improve Bleeding on probing.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Bleeding on probing
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Hyaluronic Acid Application appears to improve Clinical attachment level.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Clinical attachment level
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Hyaluronic Acid Application for HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Hyaluronic Acid Application for Periodontal probing depth.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Periodontal probing depth
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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