Last updated September 12, 2026
Key finding
Body weight remained constant over the 10-day dietary intervention period in all three groups.
This study investigated the effects of low carbohydrate ketogenic diets on glucose tolerance and insulin sensitivity in obese patients with type 2 diabetes, finding no beneficial effects.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of low carbohydrate ketogenic diets on glucose tolerance and insulin sensitivity in obese patients with type 2 diabetes, finding no beneficial effects.
These findings are significant as they challenge the assumption that ketogenic diets are beneficial for improving metabolic health in obese patients with type 2 diabetes. Clinicians should consider these results when recommending dietary interventions for managing diabetes, as the lack of improvement in key health markers suggests that such diets may not be effective for this population.
Short duration of the study (10 days) may not capture long-term effects. Limited sample size may affect the generalizability of the findings. Lack of diversity in the participant population may limit applicability.
Published in
Publication details and source links for this paper.
Aurora M, Brittany F, Andrea H, et al. Low carbohydrate ketogenic diets have no beneficial effect on glucose tolerance or insulin sensitivity in obese patients with T2D. BMJ Open Diabetes Research & Care. 2024;12(5):e004199. doi:10.1136/bmjdrc-2024-004199
Body weight remained constant across all three dietary groups.
Glucose tolerance either decreased slightly or remained unchanged in the ketogenic diet groups.
Insulin sensitivity did not improve in any of the groups.
Evidence network
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This study contributes evidence to Low-carbohydrate diet, Standard diet and 2-hour plasma glucose, Insulin sensitivity, Plasma lipid profile, and 4 more.
This study contributes evidence to
Primary intervention
Low-carbohydrate diet
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
7
Evidence pairs
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Low-carbohydrate diet → 2-hour plasma glucose
Low-carbohydrate diet → 2-hour plasma glucose
Low-carbohydrate diet → Insulin sensitivity
Low-carbohydrate diet → Insulin sensitivity
Low-carbohydrate diet → Plasma lipid profile
Low-carbohydrate diet → Plasma lipid profile
Low-carbohydrate diet → Systolic blood pressure
Low-carbohydrate diet → Systolic blood pressure
Standard diet → Body fat percentage reduction
Standard diet → Body fat percentage reduction
Evidence Library
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Low-Carbohydrate Diet Education and Body Weight, Low-Carbohydrate Diet Education and Blood Pressure.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
All studies on Low-Carbohydrate Diet Education
Contributes to Low-Carbohydrate Diet Education evidence base.
All studies measuring Blood Pressure
Measures Blood Pressure as a key outcome.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
Latest published studies
Published within the last 2 years.
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13 results
7 results
13 results
13 results
7 results
Generated from the study's connected evidence using Evidence Intelligence™.
Low-Carbohydrate Diet Education may improve blood pressure.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Systolic blood pressure
EvidenceScore™ Strong | EvidenceScore™ 83.3 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on 8 supporting studies with generally consistent results and a positive effect signal.
Low-Carbohydrate Diet Education may improve insulin resistance.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Insulin sensitivity
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 12 supporting studies with generally consistent results and a positive effect signal.
Low-Carbohydrate Diet Education may improve postprandial and ogtt glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
2-hour plasma glucose
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is based on 6 supporting studies with generally consistent results and a positive effect signal.
Standard diet may affect body weight.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Body weight
EvidenceScore™ Strong | EvidenceScore™ 78.0 | weak positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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