Last updated July 18, 2026
Key finding
A statistically significant reduction in plaque index was observed from baseline to six months.
This study compared nonsurgical periodontal therapy with and without diode laser in type 2 diabetes patients with periodontitis, finding significant improvements in several periodontal outcomes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study compared nonsurgical periodontal therapy with and without diode laser in type 2 diabetes patients with periodontitis, finding significant improvements in several periodontal outcomes.
These findings suggest that incorporating diode laser therapy into nonsurgical periodontal treatment may enhance clinical outcomes for patients with type 2 diabetes and periodontitis, potentially leading to better overall health management for this population.
Non-randomized design may introduce bias Sample size not specified, limiting generalizability Lack of long-term follow-up data
Published in
Publication details and source links for this paper.
Rupasree G, P. SR, Mehjubah M, Mounica B, Naga JC, Narendra DJ. A comparative study of nonsurgical periodontal therapy with or without diode laser in patients with type 2 diabetes mellitus and periodontitis. Journal of Pharmacy & Bioallied Sciences. 2025;17(Suppl 5):S3728-S3731. doi:10.4103/jpbs.jpbs_432_25
Significant reduction in plaque index (-0.873 score, p=0.001)
Significant reduction in gingival index (-0.977 score, p=0.001)
Significant reduction in periodontal probing depth (-2.315 mm, p=0.001)
Significant improvement in clinical attachment (+2.346 mm, p=0.001)
Significant reduction in HbA1c levels (-1.942%, p=0.001) in the laser group
Evidence network
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This study contributes evidence to Non-surgical periodontal treatment and Clinical attachment level, Gingival Index (GI), Periodontal probing depth, and 2 more.
This study contributes evidence to
Primary intervention
Non-surgical periodontal treatment
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
5
Evidence pairs
310
Related studies
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Non-surgical periodontal treatment → Clinical attachment level
Non-surgical periodontal treatment → Clinical attachment level
Non-surgical periodontal treatment → Gingival Index (GI)
Non-surgical periodontal treatment → Gingival Index (GI)
Non-surgical periodontal treatment → Periodontal probing depth
Non-surgical periodontal treatment → Periodontal probing depth
Non-surgical periodontal treatment → Plaque Index (PI)
Non-surgical periodontal treatment → Plaque Index (PI)
Non-surgical periodontal treatment → Reduction in Hemoglobin A1C levels
Non-surgical periodontal treatment → Reduction in Hemoglobin A1C levels
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Non-surgical periodontal treatment and Clinical attachment level, Non-surgical periodontal treatment and Periodontal probing depth.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Periodontal probing depth
Measures Periodontal probing depth as a key outcome.
All studies measuring Clinical attachment level
Measures Clinical attachment level as a key outcome.
All studies on Non-surgical periodontal treatment
Contributes to Non-surgical periodontal treatment evidence base.
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Published within the last 2 years.
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10 results
11 results
10 results
10 results
11 results
Generated from the study's connected evidence using Evidence Intelligence™.
Non-surgical periodontal treatment may improve Clinical attachment level.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Clinical attachment level
EvidenceScore™ Strong | EvidenceScore™ 84.4 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment may improve Periodontal probing depth.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Periodontal probing depth
EvidenceScore™ Strong | EvidenceScore™ 83.4 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment appears to improve Plaque Index (PI).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Plaque Index (PI)
EvidenceScore™ Strong | EvidenceScore™ 81.9 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment appears to improve Gingival Index (GI).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Gingival Index (GI)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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