Last updated August 22, 2026
Key finding
All four patients successfully cleared OGTT.
This study examined four patients with type 2 diabetes who achieved remission through a lifestyle modification program, showing significant improvements in key health metrics.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study examined four patients with type 2 diabetes who achieved remission through a lifestyle modification program, showing significant improvements in key health metrics.
These findings highlight the potential of lifestyle interventions in managing type 2 diabetes, suggesting that such approaches could be a viable alternative to pharmacological treatments for certain patients. This could lead to improved patient outcomes and reduced healthcare costs associated with diabetes management.
Small sample size limits generalizability. Lack of a control group prevents comparison. Effectiveness of the intervention remains unclear.
Published in
Publication details and source links for this paper.
Pramod T, Nidhi K, Anagha V, Maheshkumar K, Venugopal V. A case series of four patients achieving remission of type 2 diabetes through lifestyle modification. Journal of Family Medicine and Primary Care. 2023;12(9):2168-2171. doi:10.4103/jfmpc.jfmpc_2282_22
All four patients successfully cleared OGTT.
HbA1c values reduced to less than 6.5% without any diabetes medications.
Weight loss percentage varied between 9.4% and 25.3% from baseline.
Evidence network
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This study contributes evidence to Holistic Transformation Program and 2-hour plasma glucose, HbA1c normalization to less than 6.5%, Percentage weight loss after 12 weeks.
This study contributes evidence to
Primary intervention
Holistic Transformation Program
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
3
Evidence pairs
1037
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Holistic Transformation Program → 2-hour plasma glucose
Holistic Transformation Program → 2-hour plasma glucose
Holistic Transformation Program → HbA1c normalization to less than 6.5%
Holistic Transformation Program → HbA1c normalization to less than 6.5%
Holistic Transformation Program → Percentage weight loss after 12 weeks
Holistic Transformation Program → Percentage weight loss after 12 weeks
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Holistic Transformation Program and Postprandial and OGTT Glucose, Holistic Transformation Program and HbA1c normalization to less than 6.5%.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c normalization to less than 6.5%
Measures HbA1c normalization to less than 6.5% as a key outcome.
All studies on Holistic Transformation Program
Contributes to Holistic Transformation Program evidence base.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
All studies measuring Weight Loss Outcomes
Measures Weight Loss Outcomes as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Holistic Transformation Program appears to improve 2-hour plasma glucose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
2-hour plasma glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Holistic Transformation Program appears to lower HbA1c normalization to less than 6.5%.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c normalization to less than 6.5%
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Holistic Transformation Program appears to affect percentage weight loss after 12 weeks.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Percentage weight loss after 12 weeks
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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