Last updated August 22, 2026
Key finding
hsCRP levels decreased only in response to LCD (p<0.05).
This study investigated the effects of a low-carbohydrate, high-fat diet on endothelial function in individuals with type 2 diabetes, finding no adverse effects.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the effects of a low-carbohydrate, high-fat diet on endothelial function in individuals with type 2 diabetes, finding no adverse effects.
Understanding the impact of dietary choices on vascular health is crucial for managing type 2 diabetes. This study suggests that a low-carbohydrate, high-fat diet may be a viable option for patients without negatively affecting endothelial function, which is important for cardiovascular health.
The study's sample size may limit generalizability. The duration of the study may not capture long-term effects. Potential confounding factors were not fully controlled.
Published in
Publication details and source links for this paper.
Eva MG, Thomas BO, Camilla DH, et al. A low-carbohydrate diet high in fat does not adversely affect endothelial function in type 2 diabetes. Cardiovascular Diabetology. 2023;22:212. doi:10.1186/s12933-023-01956-8
Flow-mediated vasodilation (FMD) showed no change after six months (p=0.34).
Nitroglycerine-induced vasodilation (NID) remained unchanged in both groups (p=0.53).
High-sensitivity C-reactive protein (hsCRP) levels decreased in the low-carbohydrate diet group (p<0.05).
Interleukin-6 (IL-6) levels did not decrease in the low-carbohydrate group compared to control (p=0.25).
Evidence network
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This study contributes evidence to Low-carbohydrate diet and Brachial artery flow-mediated dilation (FMD), C-reactive protein, Interleukin-6 (IL-6), and 1 more.
This study contributes evidence to
Primary intervention
Low-carbohydrate diet
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
4
Evidence pairs
150
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Low-carbohydrate diet → Brachial artery flow-mediated dilation (FMD)
Low-carbohydrate diet → Brachial artery flow-mediated dilation (FMD)
Low-carbohydrate diet → C-reactive protein
Low-carbohydrate diet → C-reactive protein
Low-carbohydrate diet → Interleukin-6 (IL-6)
Low-carbohydrate diet → Interleukin-6 (IL-6)
Low-carbohydrate diet → Nitroglycerine-induced vasodilation assessed by ultrasound in the brachial artery
Low-carbohydrate diet → Nitroglycerine-induced vasodilation assessed by ultrasound in the brachial artery
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Low-Carbohydrate Diet Education and Inflammatory Markers, Low-Carbohydrate Diet Education and Cardiovascular Outcomes.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Inflammatory Markers
Measures Inflammatory Markers as a key outcome.
All studies on Low-Carbohydrate Diet Education
Contributes to Low-Carbohydrate Diet Education evidence base.
All studies measuring Cardiovascular Outcomes
Measures Cardiovascular Outcomes as a key outcome.
Jump to pre-filtered views in Evidence Explorer.
3 results
1 results
3 results
3 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Low-Carbohydrate Diet Education may improve inflammatory markers.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Interleukin-6 (IL-6)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 4 supporting studies with generally consistent results and a positive effect signal.
Current evidence does not show a clear benefit of Low-Carbohydrate Diet Education for cardiovascular outcomes.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Brachial artery flow-mediated dilation (FMD)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Low-carbohydrate diet for nitroglycerine-induced vasodilation assessed by ultrasound in the brachial artery.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Nitroglycerine-induced vasodilation assessed by ultrasound in the brachial artery
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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