Last updated September 3, 2026
Key finding
There was a significant association between the treatment groups and ISI after the trial (post-trial), p = 0.0001.
This study investigated the effects of magnesium and potassium supplementation on insomnia in diabetic patients, finding significant improvements in insomnia severity and hormonal levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the effects of magnesium and potassium supplementation on insomnia in diabetic patients, finding significant improvements in insomnia severity and hormonal levels.
Insomnia is a common issue among diabetic patients, impacting their overall health and quality of life. The findings suggest that magnesium and potassium supplementation could be a simple and effective strategy to alleviate sleep disturbances, potentially leading to better management of diabetes and improved patient outcomes.
The study's sample size and demographic diversity were not specified. The long-term effects of supplementation were not assessed. Potential confounding factors were not fully controlled.
Published in
Publication details and source links for this paper.
Sidra K, Shahid B, Riffat M, et al. The Effect of Magnesium and Potassium Supplementation on Insomnia in Diabetic Patients: A Randomized Controlled Trial. Frontiers in Endocrinology. 2024;15:1370733. doi:10.3389/fendo.2024.1370733
The magnesium group showed a significant reduction in ISI score by -1.5, p = 0.0001.
Serum cortisol levels decreased significantly in the potassium group by -9.75 µg/dL, p = 0.001.
The combination group demonstrated a decrease in serum melatonin by -0.62 pg/mL, p = 0.001.
Evidence network
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This study contributes evidence to Combined magnesium and potassium supplements, Magnesium oxide, Potassium and Serum cortisol, Serum melatonin.
This study contributes evidence to
Primary intervention
Combined magnesium and potassium supplements
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
6
Evidence pairs
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Related studies
Core evidence
The primary outcomes reported in this study.
Combined magnesium and potassium supplements → Serum cortisol
Combined magnesium and potassium supplements → Serum cortisol
Combined magnesium and potassium supplements → Serum melatonin
Combined magnesium and potassium supplements → Serum melatonin
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Magnesium Supplements and Serum cortisol, Magnesium Supplements and Serum melatonin.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Supplements
Curated evidence collections and hubs this study is part of.
All studies on Magnesium Supplements
Contributes to Magnesium Supplements evidence base.
All studies measuring Serum cortisol
Measures Serum cortisol as a key outcome.
All studies measuring Serum melatonin
Measures Serum melatonin as a key outcome.
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Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Combined magnesium and potassium supplements appears to improve serum cortisol.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Serum cortisol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Combined magnesium and potassium supplements appears to improve serum melatonin.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Serum melatonin
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Magnesium oxide appears to improve serum cortisol.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Serum cortisol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Magnesium oxide appears to improve serum melatonin.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Serum melatonin
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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