NoneNo Change
C-reactive protein
Magnesium oxide → C-reactive protein
Magnesium oxide → C-reactive protein
Evidence profile
NoneNo ChangeMetabolic Health
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Research Summary
Analyzed using Evidence Intelligence™
Magnesium supplementation reduces fasting plasma glucose in older adults
Key finding
Magnesium supplementation significantly reduced FPG.
This study investigated the effects of magnesium oxide supplementation on glycemic control in older adults with pre-diabetes and hypomagnesemia, finding a significant reduction in fasting plasma glucose.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Some Concerns bias
Last updated June 30, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Magnesium oxide
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
Fasting Plasma Glucose (FPG)
Comparator
Placebo Group
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study investigated the effects of magnesium oxide supplementation on glycemic control in older adults with pre-diabetes and hypomagnesemia, finding a significant reduction in fasting plasma glucose.
Clinical relevance
Improving glycemic control in older adults with pre-diabetes is crucial to prevent the progression to type 2 diabetes. This study suggests that magnesium supplementation could be a simple and effective strategy to lower fasting plasma glucose, potentially aiding in diabetes prevention efforts.
Keep in mind
The study did not find significant changes in several key glycemic markers. The sample size and characteristics may limit generalizability. The effects on long-term diabetes outcomes remain unclear.
Published in
Journal Reference
Publication details and source links for this paper.
Jingxin Y, Huidi Z, Yuting L, et al. Magnesium Supplementation Improves Glycemic Control in Older Adults with Pre-Diabetes and Hypomagnesemia. Frontiers in Nutrition. 2026;13:1765308. doi:10.3389/fnut.2026.1765308
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Main Effects
Magnesium supplementation significantly reduced fasting plasma glucose by -0.497 mmol/L (p=0.003).
No significant differences were observed for insulin levels.
The reduction in insulin resistance favored the magnesium group but was not statistically significant.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Magnesium oxide and C-reactive protein, Fasting Plasma Glucose (FPG), Glycated albumin, and 4 more.
This study contributes evidence to
Primary intervention
Magnesium oxide
Primary outcomes
- C-reactive protein
- Fasting Plasma Glucose (FPG)
- Glycated albumin
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
7
Evidence pairs
7
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
3
Related topics
7
Evidence pairs
298
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 7 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
StrongDecrease
Fasting Plasma Glucose (FPG)
Magnesium oxide → Fasting Plasma Glucose (FPG)
Magnesium oxide → Fasting Plasma Glucose (FPG)
Evidence profile
StrongDecreaseGlycemic Control
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NoneNo Change
Glycated albumin
Magnesium oxide → Glycated albumin
Magnesium oxide → Glycated albumin
Evidence profile
NoneNo ChangeGlycemic Control
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NoneNo Change
HbA1c
Magnesium oxide → HbA1c
Magnesium oxide → HbA1c
Evidence profile
NoneNo ChangeGlycemic Control
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NoneNo Change
Insulin
Magnesium oxide → Insulin
Magnesium oxide → Insulin
Evidence profile
NoneNo ChangeGlycemic Control
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NoneNo Change
Insulin resistance
Magnesium oxide → Insulin resistance
Magnesium oxide → Insulin resistance
Evidence profile
NoneNo ChangeMetabolic Health
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NoneNo Change
Interleukin-6 (IL-6)
Magnesium oxide → Interleukin-6 (IL-6)
Magnesium oxide → Interleukin-6 (IL-6)
Evidence profile
NoneNo ChangeMetabolic Health
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Evidence Suggest
- Fasting plasma glucose decreased significantly by -0.497 mmol/L.
- No significant changes were noted in insulin or HbA1c levels.
- Insulin resistance reduction favored magnesium, but not statistically significant.
Who this applies to
- Older adults aged 65 and above.
- Individuals diagnosed with pre-diabetes.
- Patients with low magnesium levels.
Keep in Mind
- Results may not be applicable to younger populations.
- The study focused on short-term effects; long-term benefits are unknown.
- Further research is needed to confirm findings across diverse populations.
Between the Lines
- The study did not find significant changes in several key glycemic markers.
- The sample size and characteristics may limit generalizability.
- The effects on long-term diabetes outcomes remain unclear.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Magnesium Supplements and Fasting Glucose.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Fasting Glucose Evidence Hub
All studies measuring Fasting Glucose
1 studies
outcome_hubMeasures Fasting Glucose as a key outcome.
Magnesium Supplements Evidence Hub
All studies on Magnesium Supplements
1 studies
intervention_hubContributes to Magnesium Supplements evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Magnesium oxide and Fasting Plasma Glucose (FPG)
Intervention: Magnesium oxideOutcome: Fasting Plasma Glucose (FPG)
1 results
All studies on Magnesium oxide
Intervention: Magnesium oxide
1 results
All studies measuring Fasting Plasma Glucose (FPG)
Outcome: Fasting Plasma Glucose (FPG)
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Magnesium Supplements improve fasting glucose?
Emerging Evidence
Magnesium Supplements appears to improve Fasting Glucose.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 51.7 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Magnesium Supplements improve insulin resistance?
Limited Evidence
Current evidence does not show a clear benefit of Magnesium Supplements for Insulin Resistance.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Insulin
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study
- 2
Insulin resistance
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Magnesium Supplements improve HbA1c?
Limited Evidence
Current evidence does not show a clear benefit of Magnesium Supplements for HbA1c.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Magnesium Supplements improve inflammatory markers?
Limited Evidence
Current evidence does not show a clear benefit of Magnesium Supplements for Inflammatory Markers.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
C-reactive protein
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study
- 2
Interleukin-6 (IL-6)
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
- Only a small number of supporting studies are available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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