Last updated July 18, 2026
Key finding
Intra-group ΔeGFR levels were 10.26 mL/min/1.73 m² (p < 0.001)
This study investigated the impact of non-surgical periodontal therapy on renal function and glycaemic control in chronic kidney disease patients, finding significant improvements in eGFR and HbA1c levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the impact of non-surgical periodontal therapy on renal function and glycaemic control in chronic kidney disease patients, finding significant improvements in eGFR and HbA1c levels.
Improving renal function and glycaemic control in chronic kidney disease patients is crucial, as these conditions often coexist and can exacerbate each other. This study suggests that non-surgical periodontal therapy could be a valuable adjunctive treatment, potentially leading to better overall health outcomes for these patients.
Unclear effectiveness for some outcomes Limited generalizability due to specific population characteristics Small sample size may affect reliability Lack of long-term follow-up data
Published in
Publication details and source links for this paper.
Spyridon KK, Yiorgos AB, Sophia L, et al. The effect of non-surgical periodontal therapy on renal function and glycaemic control in chronic kidney disease patients: A randomized clinical trial. Journal of Clinical Periodontology. 2025;53(3):362-372. doi:10.1111/jcpe.70059
eGFR increased by 10.26 mL/min/1.73 m² (p < 0.001)
HbA1c decreased by 0.54% (p = 0.003)
hsCRP levels reduced by 84% (p < 0.001)
uACR showed a marginal decrease, not statistically significant
Evidence network
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This study contributes evidence to Non-surgical periodontal treatment and C-reactive protein, Estimated glomerular filtration rate, HbA1c, and 1 more.
This study contributes evidence to
Primary intervention
Non-surgical periodontal treatment
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
4
Evidence pairs
368
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Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
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Core evidence
The primary outcomes reported in this study.
Non-surgical periodontal treatment → C-reactive protein
Non-surgical periodontal treatment → C-reactive protein
Non-surgical periodontal treatment → Estimated glomerular filtration rate
Non-surgical periodontal treatment → Estimated glomerular filtration rate
Non-surgical periodontal treatment → Urinary albumin-to-creatinine ratio
Non-surgical periodontal treatment → Urinary albumin-to-creatinine ratio
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Non-surgical periodontal treatment and HbA1c, Non-surgical periodontal treatment and Inflammatory Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Non-surgical periodontal treatment
Contributes to Non-surgical periodontal treatment evidence base.
All studies measuring Inflammatory Markers
Measures Inflammatory Markers as a key outcome.
Latest published studies
Published within the last 2 years.
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10 results
5 results
10 results
10 results
5 results
Generated from the study's connected evidence using Evidence Intelligence™.
Non-surgical periodontal treatment may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 83.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment may improve C-reactive protein.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Strong | EvidenceScore™ 81.1 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Non-surgical periodontal treatment appears to improve Estimated glomerular filtration rate.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Estimated glomerular filtration rate
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Non-surgical periodontal treatment for Urinary albumin-to-creatinine ratio.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Urinary albumin-to-creatinine ratio
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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