Last updated August 16, 2026
Key finding
Changes in HbA1c in the periodontal treatment group were not significantly different with those in the control group at 3 and 6 months.
This study investigated the effects of non-surgical periodontal treatment on glycemic control in patients with type 2 diabetes. It found no significant changes in HbA1c but improvements in oxidative stress balance and quality of life.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the effects of non-surgical periodontal treatment on glycemic control in patients with type 2 diabetes. It found no significant changes in HbA1c but improvements in oxidative stress balance and quality of life.
These findings suggest that while non-surgical periodontal treatment may not directly lower blood sugar levels, it can enhance the quality of life and reduce oxidative stress in patients with type 2 diabetes. This highlights the importance of managing oral health as part of comprehensive diabetes care.
Unclear effectiveness of the intervention on HbA1c levels. Limited generalizability due to specific population characteristics. Short follow-up duration may not capture long-term effects. Lack of detailed demographic data on participants.
Published in
Publication details and source links for this paper.
Hirofumi M, Daisuke E, Takayuki M, et al. Effects of Non-Surgical Periodontal Treatment on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial. PLOS ONE. 2017;12(11):e0188171. doi:10.1371/journal.pone.0188171
HbA1c levels showed no significant difference between treatment and control groups at 3 and 6 months.
Systemic oxidative stress balance significantly improved in the treatment group compared to controls at 3 months.
Diabetes therapy-related quality of life significantly improved in the treatment group compared to controls at 3 months.
No significant differences were reported for clinical periodontal parameters.
Evidence network
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This study contributes evidence to Non-surgical periodontal treatment and Change in oxidative stress balance (Oxidative-INDEX), HbA1c, Quality of life.
This study contributes evidence to
Primary intervention
Non-surgical periodontal treatment
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
3
Evidence pairs
348
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Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Non-surgical periodontal treatment → Change in oxidative stress balance (Oxidative-INDEX)
Non-surgical periodontal treatment → Change in oxidative stress balance (Oxidative-INDEX)
Non-surgical periodontal treatment → Quality of life
Non-surgical periodontal treatment → Quality of life
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Non-surgical periodontal treatment and HbA1c, Non-surgical periodontal treatment and Change in oxidative stress balance (Oxidative-INDEX).
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Non-surgical periodontal treatment
Contributes to Non-surgical periodontal treatment evidence base.
All studies measuring Change in oxidative stress balance (Oxidative-INDEX)
Measures Change in oxidative stress balance (Oxidative-INDEX) as a key outcome.
All studies measuring Quality of Life Outcomes
Measures Quality of Life Outcomes as a key outcome.
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13 results
1 results
13 results
13 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Non-surgical periodontal treatment may improve HbA1c.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 83.8 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Non-surgical periodontal treatment appears to improve Change in oxidative stress balance (Oxidative-INDEX).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Change in oxidative stress balance (Oxidative-INDEX)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment appears to improve Quality of life.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Quality of life
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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