Last updated July 18, 2026
Key finding
The difference in glycated hemoglobin levels between baseline and two months after non-surgical periodontal therapy was statistically significant in the total sample (p=0.045).
This study explored the impact of non-surgical periodontal therapy on glycemic control in individuals with type 2 diabetes and periodontitis, finding a significant reduction in HbA1c levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study explored the impact of non-surgical periodontal therapy on glycemic control in individuals with type 2 diabetes and periodontitis, finding a significant reduction in HbA1c levels.
Improving glycemic control is crucial for individuals with type 2 diabetes, as it can reduce the risk of complications associated with the disease. This study suggests that addressing periodontal health may be an effective strategy for enhancing diabetes management, highlighting the interconnectedness of oral health and systemic conditions.
The study design was non-randomized, which may affect bias. Sample size and characteristics limit generalizability of findings. No significant changes were observed in fasting plasma glucose or C-reactive protein.
Published in
Publication details and source links for this paper.
Rafael PEL, Karolina SSV, Pierre GBDS, Luís OMC, Fernando OC. Periodontal intervention may contribute to improved glycemic control in individuals with type 2 diabetes mellitus and periodontitis. Journal of Applied Oral Science. 2025;33:e20250121. doi:10.1590/1678-7757-2025-0121
HbA1c levels decreased by 0.13% (p=0.045) after treatment.
Probing depth reduced by 0.38 mm, indicating improved periodontal health.
Gingival inflammation decreased, showing better oral health outcomes.
Evidence network
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This study contributes evidence to Non-surgical periodontal treatment and C-reactive protein, Clinical attachment level, Fasting Plasma Glucose (FPG), and 3 more.
This study contributes evidence to
Primary intervention
Non-surgical periodontal treatment
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
6
Evidence pairs
613
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Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
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Core evidence
The primary outcomes reported in this study.
Non-surgical periodontal treatment → C-reactive protein
Non-surgical periodontal treatment → C-reactive protein
Non-surgical periodontal treatment → Clinical attachment level
Non-surgical periodontal treatment → Clinical attachment level
Non-surgical periodontal treatment → Fasting Plasma Glucose (FPG)
Non-surgical periodontal treatment → Fasting Plasma Glucose (FPG)
Non-surgical periodontal treatment → Periodontal probing depth
Non-surgical periodontal treatment → Periodontal probing depth
Non-surgical periodontal treatment → Reduction in gingival inflammation after non-surgical periodontal therapy
Non-surgical periodontal treatment → Reduction in gingival inflammation after non-surgical periodontal therapy
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Non-surgical periodontal treatment and Clinical attachment level, Non-surgical periodontal treatment and HbA1c.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Clinical attachment level
Measures Clinical attachment level as a key outcome.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Non-surgical periodontal treatment
Contributes to Non-surgical periodontal treatment evidence base.
Latest published studies
Published within the last 2 years.
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10 results
10 results
10 results
10 results
10 results
Generated from the study's connected evidence using Evidence Intelligence™.
Non-surgical periodontal treatment may improve Clinical attachment level.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Clinical attachment level
EvidenceScore™ Strong | EvidenceScore™ 84.4 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 83.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment may improve Periodontal probing depth.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Periodontal probing depth
EvidenceScore™ Strong | EvidenceScore™ 83.4 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment may improve C-reactive protein.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Strong | EvidenceScore™ 81.1 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
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