Last updated August 22, 2026
Key finding
Stool frequency did not differ by group or study phase.
Prebiotic supplement added to metformin in youth with type 2 diabetes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
Prebiotic supplement added to metformin in youth with type 2 diabetes.
This study evaluated Prebiotic supplement added to metformin in youth with type 2 diabetes.
Limitations were not clearly described in the extracted text.
Published in
Publication details and source links for this paper.
Sydney AD, Sidharth M, Katrina BD, et al. Prebiotic Supplementation Improves Tolerability of Metformin in Youth with Type 2 Diabetes: A Pilot Study. Frontiers in Endocrinology. 2023;14:1125187. doi:10.3389/fendo.2023.1125187
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Prebiotic supplementation and Abnormal stool frequency, Composite Lower GI Symptoms, Gut microbiota diversity, and 3 more.
This study contributes evidence to
Primary intervention
Prebiotic supplementation
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
6
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Prebiotic supplementation → Abnormal stool frequency
Prebiotic supplementation → Abnormal stool frequency
Prebiotic supplementation → Composite Lower GI Symptoms
Prebiotic supplementation → Composite Lower GI Symptoms
Prebiotic supplementation → Gut microbiota diversity
Prebiotic supplementation → Gut microbiota diversity
Prebiotic supplementation → Markers of metabolic endotoxemia
Prebiotic supplementation → Markers of metabolic endotoxemia
Prebiotic supplementation → Serious adverse events
Prebiotic supplementation → Serious adverse events
Prebiotic supplementation → Stool consistency (stool form)
Prebiotic supplementation → Stool consistency (stool form)
Evidence Library
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Prebiotic supplementation and Gastrointestinal Adverse Events, Prebiotic supplementation and Composite Lower GI Symptoms.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Composite Lower GI Symptoms
Measures Composite Lower GI Symptoms as a key outcome.
All studies measuring Gastrointestinal Adverse Events
Measures Gastrointestinal Adverse Events as a key outcome.
All studies on Prebiotic supplementation
Contributes to Prebiotic supplementation evidence base.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of Prebiotic supplementation for Abnormal stool frequency.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Abnormal stool frequency
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Prebiotic supplementation for Composite Lower GI Symptoms.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Composite Lower GI Symptoms
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Prebiotic supplementation for Gut microbiota diversity.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Gut microbiota diversity
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Prebiotic supplementation for Markers of metabolic endotoxemia.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Markers of metabolic endotoxemia
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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