Last updated September 12, 2026
Key finding
Fasting blood glucose decreased significantly from baseline.
This study investigated the effects of multi-strain probiotic supplementation on glucose and lipid metabolism in patients with type 2 diabetes. It found significant reductions in fasting and postprandial blood glucose levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of multi-strain probiotic supplementation on glucose and lipid metabolism in patients with type 2 diabetes. It found significant reductions in fasting and postprandial blood glucose levels.
These findings suggest that multi-strain probiotics could be a beneficial dietary intervention for managing blood sugar levels in individuals with type 2 diabetes. This could provide an additional strategy for patients seeking to improve their metabolic health alongside traditional treatments.
Limited sample size may affect generalizability Short duration of the study may not capture long-term effects Lack of significant changes in other metabolic markers
Published in
Publication details and source links for this paper.
Asli K, Orcun Z, Ilgin YS, Nevin T, Ozlem Y. Effects of Multi-Strain Probiotic Supplementation on Glucose and Lipid Metabolism in Patients with Type 2 Diabetes: A Prospective Controlled Clinical Trial. BMC Nutrition. 2026;12:132. doi:10.1186/s40795-026-01354-9
Fasting Plasma Glucose decreased by 19.08 mg/dL (p=0.001)
Postprandial blood glucose decreased by 21.31 mg/dL (p=0.003)
No significant changes in HbA1c levels
No significant changes in LDL-C and Non-HDL-C levels
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Multi-species synbiotic (12 probiotic strains + FOS prebiotic) and C-reactive protein, Fasting Plasma Glucose (FPG), Glucose iAUC (OGTT), and 4 more.
This study contributes evidence to
Primary intervention
Multi-species synbiotic (12 probiotic strains + FOS prebiotic)
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
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Evidence pairs
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → C-reactive protein
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → C-reactive protein
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Fasting Plasma Glucose (FPG)
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Fasting Plasma Glucose (FPG)
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Glucose iAUC (OGTT)
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Glucose iAUC (OGTT)
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → HbA1c
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → HbA1c
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → LDL cholesterol
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → LDL cholesterol
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Malondialdehyde (MDA)
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Malondialdehyde (MDA)
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Very-low-density lipoprotein cholesterol
Multi-species synbiotic (12 probiotic strains + FOS prebiotic) → Very-low-density lipoprotein cholesterol
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Probiotics and Synbiotics and Fasting Glucose, Probiotics and Synbiotics and HbA1c.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies on Probiotics and Synbiotics
Contributes to Probiotics and Synbiotics evidence base.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
Latest published studies
Published within the last 2 years.
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5 results
4 results
5 results
5 results
4 results
Generated from the study's connected evidence using Evidence Intelligence™.
Probiotics and Synbiotics may improve adipokine and angiogenic markers.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
LDL cholesterol
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 11 supporting studies with generally consistent results and a positive effect signal.
Probiotics and Synbiotics appear to lower HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 13 supporting studies with consistent results and a positive effect signal.
Probiotics and Synbiotics appear to improve fasting glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 83.1 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 14 supporting studies with generally consistent results and a positive effect signal.
Probiotics and Synbiotics may improve inflammatory markers.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 6 supporting studies with generally consistent results and a positive effect signal.
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