Last updated September 3, 2026
Key finding
After 3 months, there were no statistically significant differences in mitochondrial respiration within or between the TRE and control groups.
This study investigated the effects of time-restricted eating on mitochondrial bioenergetics in individuals at high risk of type 2 diabetes, finding no significant differences.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of time-restricted eating on mitochondrial bioenergetics in individuals at high risk of type 2 diabetes, finding no significant differences.
Understanding the impact of dietary interventions like time-restricted eating on mitochondrial function is crucial for developing effective strategies to prevent type 2 diabetes. This study suggests that simply changing eating patterns may not be sufficient to influence cellular energy metabolism in at-risk populations.
Limited sample size may affect the generalizability of the findings. Short duration of the intervention might not capture long-term effects. Lack of diversity in the study population could limit applicability.
Published in
Publication details and source links for this paper.
Joana MLDM, Martin BB, Verena HJ, et al. Time-restricted eating does not alter mitochondrial bioenergetics in individuals at high risk of type 2 diabetes. Scientific Reports. 2025;15:10175. doi:10.1038/s41598-025-94652-4
No significant differences in mitochondrial basal respiration-control (OCR) after 3 months.
No significant differences in mitochondrial spare respiration-control (OCR) after 3 months.
No significant differences in mitochondrial ATP-linked respiration-control (OCR) after 3 months.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Time-Restricted Eating (TRE) and Mitochondrial ATP-linked respiration-control (OCR), Mitochondrial ATP-linked respiration-etomoxir (OCR), Mitochondrial basal respiration-control (OCR), and 7 more.
This study contributes evidence to
Primary intervention
Time-Restricted Eating (TRE)
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
10
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Time-Restricted Eating (TRE) → Mitochondrial ATP-linked respiration-control (OCR)
Time-Restricted Eating (TRE) → Mitochondrial ATP-linked respiration-control (OCR)
Time-Restricted Eating (TRE) → Mitochondrial ATP-linked respiration-etomoxir (OCR)
Time-Restricted Eating (TRE) → Mitochondrial ATP-linked respiration-etomoxir (OCR)
Time-Restricted Eating (TRE) → Mitochondrial basal respiration-control (OCR)
Time-Restricted Eating (TRE) → Mitochondrial basal respiration-control (OCR)
Time-Restricted Eating (TRE) → Mitochondrial basal respiration-etomoxir (OCR)
Time-Restricted Eating (TRE) → Mitochondrial basal respiration-etomoxir (OCR)
Time-Restricted Eating (TRE) → Mitochondrial maximum respiration-control (OCR)
Time-Restricted Eating (TRE) → Mitochondrial maximum respiration-control (OCR)
Time-Restricted Eating (TRE) → Mitochondrial maximum respiration-etomoxir (OCR)
Time-Restricted Eating (TRE) → Mitochondrial maximum respiration-etomoxir (OCR)
Time-Restricted Eating (TRE) → Mitochondrial spare respiration-control (OCR)
Time-Restricted Eating (TRE) → Mitochondrial spare respiration-control (OCR)
Time-Restricted Eating (TRE) → Mitochondrial spare respiration-etomoxir (OCR)
Time-Restricted Eating (TRE) → Mitochondrial spare respiration-etomoxir (OCR)
Time-Restricted Eating (TRE) → Non-mitochondrial respiration-control (OCR)
Time-Restricted Eating (TRE) → Non-mitochondrial respiration-control (OCR)
Time-Restricted Eating (TRE) → Non-mitochondrial respiration-etomoxir (OCR)
Time-Restricted Eating (TRE) → Non-mitochondrial respiration-etomoxir (OCR)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Time-Restricted Eating (TRE) and Mitochondrial ATP-linked respiration-control (OCR), Time-Restricted Eating (TRE) and Mitochondrial ATP-linked respiration-etomoxir (OCR).
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Mitochondrial ATP-linked respiration-control (OCR)
Measures Mitochondrial ATP-linked respiration-control (OCR) as a key outcome.
All studies measuring Mitochondrial ATP-linked respiration-etomoxir (OCR)
Measures Mitochondrial ATP-linked respiration-etomoxir (OCR) as a key outcome.
All studies on Time-Restricted Eating (TRE)
Contributes to Time-Restricted Eating (TRE) evidence base.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of Time-Restricted Eating (TRE) for mitochondrial atp-linked respiration-control (OCR).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Mitochondrial ATP-linked respiration-control (OCR)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Time-Restricted Eating (TRE) for mitochondrial atp-linked respiration-etomoxir (OCR).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Mitochondrial ATP-linked respiration-etomoxir (OCR)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Time-Restricted Eating (TRE) for mitochondrial basal respiration-control (OCR).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Mitochondrial basal respiration-control (OCR)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Time-Restricted Eating (TRE) for mitochondrial basal respiration-etomoxir (OCR).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Mitochondrial basal respiration-etomoxir (OCR)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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