Last updated July 3, 2026
Key finding
The vitamin D3 group demonstrated a significant increase in serum 25(OH) vitamin D3 levels compared to the placebo group (p < 0.001).
This study investigated the effects of Vitamin D3 supplementation on oxidative stress markers and NLRP3 gene expression in patients with Type 2 Diabetes, finding significant increases in vitamin D3 levels and reductions in NLRP3 expression.
Quick read
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the effects of Vitamin D3 supplementation on oxidative stress markers and NLRP3 gene expression in patients with Type 2 Diabetes, finding significant increases in vitamin D3 levels and reductions in NLRP3 expression.
These findings suggest that Vitamin D3 supplementation may have beneficial effects on inflammation in Type 2 Diabetes patients, potentially aiding in the management of the disease. Understanding the role of vitamin D in metabolic processes could lead to improved treatment strategies for diabetes-related complications.
Limited sample size may affect generalizability. Short duration of supplementation could limit long-term applicability. Lack of diversity in the participant population may influence results.
Published in
Publication details and source links for this paper.
Shadi B, Yaser M, Gholamreza AS, Mohammad M, Azam RF. Effects of Vitamin D3 Supplementation on Oxidative Stress Markers and NLRP3 Gene Expression in Patients with Type 2 Diabetes. Health Science Reports. 2025;8(5):e70770. doi:10.1002/hsr2.70770
Vitamin D3 levels increased by 21 ng/mL in the supplementation group (p < 0.001).
NLRP3 gene expression decreased by 1.5 fold in the vitamin D3 group (p < 0.02).
No significant changes in malondialdehyde levels (p = 0.20).
No significant changes in total antioxidant capacity (p = 0.81).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Vitamin D supplementation and Malondialdehyde (MDA), NLRP3 gene expression, Serum 25-hydroxyvitamin D, and 2 more.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
5
Evidence pairs
230
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
The primary outcomes reported in this study.
Vitamin D supplementation → Malondialdehyde (MDA)
Vitamin D supplementation → Malondialdehyde (MDA)
Vitamin D supplementation → NLRP3 gene expression
Vitamin D supplementation → NLRP3 gene expression
Vitamin D supplementation → Serum 25-hydroxyvitamin D
Vitamin D supplementation → Serum 25-hydroxyvitamin D
Vitamin D supplementation → Total Antioxidant Capacity (TAC)
Vitamin D supplementation → Total Antioxidant Capacity (TAC)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and Adipokine and Angiogenic Markers, Vitamin D supplementation and Oxidative Stress Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies on Vitamin D supplementation
Contributes to Vitamin D supplementation evidence base.
All studies measuring Oxidative Stress Markers
Measures Oxidative Stress Markers as a key outcome.
Latest published studies
Published within the last 2 years.
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5 results
3 results
5 results
5 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Vitamin D supplementation appears to improve Serum 25-hydroxyvitamin D.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Serum 25-hydroxyvitamin D
EvidenceScore™ Strong | EvidenceScore™ 79.9 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation may improve Malondialdehyde (MDA).
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Malondialdehyde (MDA)
EvidenceScore™ Strong | EvidenceScore™ 77.4 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation appears to improve NLRP3 gene expression.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
NLRP3 gene expression
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Vitamin D supplementation for Thiol group.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Thiol group
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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