Last updated September 10, 2026
Key finding
WPI reduced the postprandial glucose response by up to 30% (p = 0.001).
This study examined the effects of whey protein and mulberry leaf extract on postprandial glycemic response, finding significant reductions in glucose levels with these interventions.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study examined the effects of whey protein and mulberry leaf extract on postprandial glycemic response, finding significant reductions in glucose levels with these interventions.
These findings are clinically significant as they suggest that incorporating whey protein and mulberry leaf extract into meals could be an effective strategy for managing postprandial glucose levels, particularly for individuals at risk of diabetes or those seeking to control their blood sugar levels. This could lead to better dietary recommendations and interventions for glycemic control.
The study did not include a diverse population, limiting generalizability. Sample size and duration may not provide long-term effectiveness data. The effects of other dietary factors were not controlled.
Published in
Publication details and source links for this paper.
Nele G, Celia F, Andreas R, et al. Postprandial Glycemic Response: Optimizing Nutritional Solutions with Whey Protein and Mulberry Leaf Extract. Nutrients. 2022;14(13):2674. doi:10.3390/nu14132674
Whey Protein Isolate reduced postprandial glucose response by 30% (p = 0.001).
Whey Protein Microgel reduced postprandial glucose response by 34% (p < 0.001).
Mulberry Leaf Extract reduced postprandial glucose response by 26% (p = 0.002).
Evidence network
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This study contributes evidence to Mulberry leaf extract (MLE) blend, whey protein 20g and Glucose iAUC (OGTT).
This study contributes evidence to
Primary intervention
Mulberry leaf extract (MLE) blend
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
2
Evidence pairs
661
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Mulberry leaf extract (MLE) blend → Glucose iAUC (OGTT)
Mulberry leaf extract (MLE) blend → Glucose iAUC (OGTT)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on whey protein 20g and Postprandial and OGTT Glucose, Mulberry leaf extract (MLE) blend and Postprandial and OGTT Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
All studies on whey protein 20g
Contributes to whey protein 20g evidence base.
All studies on Mulberry leaf extract (MLE) blend
Contributes to Mulberry leaf extract (MLE) blend evidence base.
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3 results
2 results
3 results
2 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
whey protein 20g appears to improve glucose iauc (OGTT).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Glucose iAUC (OGTT)
EvidenceScore™ Strong | EvidenceScore™ 78.6 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Mulberry leaf extract (MLE) blend appears to improve glucose iauc (OGTT).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Glucose iAUC (OGTT)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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