Last updated August 25, 2026
Key finding
Weight loss at week 16 was similar between HC and RC (0.15 kg; 95% CI: -1.86, 2.16 kg; P = 0.88).
This study evaluated the effects of dietary carbohydrate restriction, time-restricted eating, and exercise on weight loss and glycemic control in adults with prediabetes. Results showed similar weight loss between high-carbohydrate and reduced carbohydrate diets.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of dietary carbohydrate restriction, time-restricted eating, and exercise on weight loss and glycemic control in adults with prediabetes. Results showed similar weight loss between high-carbohydrate and reduced carbohydrate diets.
Understanding effective dietary strategies for weight loss and glycemic control is crucial for managing prediabetes. This study provides insights into how different dietary approaches can yield similar results, helping clinicians tailor interventions to individual preferences and needs.
The study did not measure long-term effects beyond 16 weeks. Results may not be generalizable to populations outside of prediabetes. No significant differences were found in several glycemic markers.
Published in
Publication details and source links for this paper.
Katie ME, Aseel EZ, Navneet KB, et al. Dietary carbohydrate restriction, time-restricted eating, and exercise for weight loss and glycemic control in adults with prediabetes: A randomized controlled trial. The American Journal of Clinical Nutrition. 2025;122(4):1093-1102. doi:10.1016/j.ajcnut.2025.07.034
Weight loss at week 16 was similar between HC and RC diets (0.15 kg; P = 0.88).
Fasting plasma glucose decreased by 8.0 mg/dL.
Changes in HbA1c were not significantly different between HC and RC.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Low-carbohydrate diet, Time-Restricted Eating (TRE) and Fasting Plasma Glucose (FPG), Fasting insulin levels, HbA1c, and 3 more.
This study contributes evidence to
Primary intervention
Low-carbohydrate diet
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Evidence pairs
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Low-carbohydrate diet → Fasting insulin levels
Low-carbohydrate diet → Fasting insulin levels
Low-carbohydrate diet → Fasting Plasma Glucose (FPG)
Low-carbohydrate diet → Fasting Plasma Glucose (FPG)
Low-carbohydrate diet → Quantitative Insulin Sensitivity Check Index (QUICKI)
Low-carbohydrate diet → Quantitative Insulin Sensitivity Check Index (QUICKI)
Low-carbohydrate diet → Weight loss dependent effect on HbA1c
Low-carbohydrate diet → Weight loss dependent effect on HbA1c
Evidence Library
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Low-Carbohydrate Diet Education and HbA1c, Low-Carbohydrate Diet Education and Body Weight.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Low-Carbohydrate Diet Education
Contributes to Low-Carbohydrate Diet Education evidence base.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
Latest published studies
Published within the last 2 years.
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19 results
10 results
19 results
19 results
10 results
Generated from the study's connected evidence using Evidence Intelligence™.
Low-Carbohydrate Diet Education may improve insulin resistance.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Fasting insulin levels
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 9 supporting studies with generally consistent results and a positive effect signal.
Low-Carbohydrate Diet Education may lower HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 85.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on 22 supporting studies with generally consistent results and a positive effect signal.
Low-Carbohydrate Diet Education may improve fasting glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 84.3 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 10 supporting studies with consistent results and a positive effect signal.
Time-Restricted Eating (TRE) may affect body weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Body weight
EvidenceScore™ Strong | EvidenceScore™ 82.7 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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