Last updated July 22, 2026
Key finding
The difference between the hs-CRP levels at baseline and the values at 3 months was statistically significant (z = -3.71, p < 0.001).
This study evaluated the effects of intensive periodontal treatment on lipid profiles and endothelial function in diabetic patients, finding significant improvements in endothelial function but no changes in lipid levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of intensive periodontal treatment on lipid profiles and endothelial function in diabetic patients, finding significant improvements in endothelial function but no changes in lipid levels.
Improving endothelial function is crucial for diabetic patients, as they are at higher risk for cardiovascular diseases. This study suggests that intensive periodontal treatment may offer additional cardiovascular benefits beyond oral health, highlighting the importance of dental care in managing diabetes.
The study did not assess long-term effects beyond the 3-month follow-up. Sample size and demographic characteristics may limit generalizability. No differences in lipid profiles were observed, which may affect clinical relevance.
Published in
Publication details and source links for this paper.
Biagio R, Elisabetta F, Erda Q, et al. The Impact of Intensive Periodontal Treatment on Lipid Profile and Endothelial Function in Diabetic Patients. Biomedicines. 2022;10(10):2524. doi:10.3390/biomedicines10102524
Intensive treatment group showed a significant increase in flow-mediated vasodilation (p < 0.001).
Clinical attachment levels improved significantly with intensive treatment (z = -5.85, p < 0.001).
Probing pocket depth decreased significantly in the intensive treatment group (z = -4.87, p < 0.001).
Evidence network
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This study contributes evidence to Intensive Periodontal Treatment and Brachial artery flow-mediated dilation (FMD), C-reactive protein, Clinical attachment level, and 6 more.
This study contributes evidence to
Primary intervention
Intensive Periodontal Treatment
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
9
Evidence pairs
415
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Intensive Periodontal Treatment → Brachial artery flow-mediated dilation (FMD)
Intensive Periodontal Treatment → Brachial artery flow-mediated dilation (FMD)
Intensive Periodontal Treatment → C-reactive protein
Intensive Periodontal Treatment → C-reactive protein
Intensive Periodontal Treatment → Clinical attachment level
Intensive Periodontal Treatment → Clinical attachment level
Intensive Periodontal Treatment → HDL cholesterol
Intensive Periodontal Treatment → HDL cholesterol
Intensive Periodontal Treatment → LDL cholesterol
Intensive Periodontal Treatment → LDL cholesterol
Intensive Periodontal Treatment → Periodontal probing depth
Intensive Periodontal Treatment → Periodontal probing depth
Intensive Periodontal Treatment → Total cholesterol
Intensive Periodontal Treatment → Total cholesterol
Intensive Periodontal Treatment → Triglycerides
Intensive Periodontal Treatment → Triglycerides
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Intensive Periodontal Treatment and Cardiovascular Outcomes, Intensive Periodontal Treatment and Inflammatory Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring Cardiovascular Outcomes
Measures Cardiovascular Outcomes as a key outcome.
All studies measuring Inflammatory Markers
Measures Inflammatory Markers as a key outcome.
All studies on Intensive Periodontal Treatment
Contributes to Intensive Periodontal Treatment evidence base.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Intensive Periodontal Treatment appears to improve C-reactive protein.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Intensive Periodontal Treatment appears to improve Clinical attachment level.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Clinical attachment level
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Intensive Periodontal Treatment appears to improve Periodontal probing depth.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Periodontal probing depth
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Intensive Periodontal Treatment for Brachial artery flow-mediated dilation (FMD).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Brachial artery flow-mediated dilation (FMD)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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