Last updated August 16, 2026
Key finding
Higher SOD1 mRNA levels were observed in Control individuals at baseline.
This study investigated the changes in IRS2 and SOD1 expression following non-surgical periodontal therapy in individuals with Type 2 Diabetes Mellitus and periodontitis, revealing significant alterations over time.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the changes in IRS2 and SOD1 expression following non-surgical periodontal therapy in individuals with Type 2 Diabetes Mellitus and periodontitis, revealing significant alterations over time.
Understanding the relationship between periodontal therapy and metabolic markers like IRS2 and SOD1 is crucial for improving treatment strategies in patients with Type 2 Diabetes Mellitus. These findings suggest that managing oral health may have broader implications for metabolic control and overall health in diabetic patients.
Unclear effectiveness of the intervention due to limited data. Potential confounding factors not fully accounted for. Sample size and population diversity may limit generalizability.
Published in
Publication details and source links for this paper.
François IDC, Renata CLS, Maurício GGM, et al. Longitudinal Changes in IRS2 and SOD1 Expression Following Non-Surgical Periodontal Therapy in Individuals with Type 2 Diabetes Mellitus and Periodontitis. Biomedicines. 2026;14(4):742. doi:10.3390/biomedicines14040742
Higher SOD1 mRNA levels were observed in Control individuals at baseline (1.5 increase, p=0.01).
IRS2 mRNA levels were higher in individuals with Periodontitis at baseline, followed by a significant reduction over time (-1.2 decrease, p=0.05).
Salivary SOD enzymatic activity was lower in individuals from the T2DM_poorly_Controlled+P and T2DM_well_Controlled+P groups (-0.5 U/mL decrease, p=0.03).
Predominant IRS-2 immunopositive cells were found in the T2DM+P groups (2 increase, p=0.02).
Evidence network
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This study contributes evidence to Non-surgical periodontal treatment and IRS2 levels in gingival biopsies, IRS2 mRNA levels in peripheral blood mononuclear cells, Salivary SOD enzymatic activity, and 1 more.
This study contributes evidence to
Primary intervention
Non-surgical periodontal treatment
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
4
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Non-surgical periodontal treatment → IRS2 levels in gingival biopsies
Non-surgical periodontal treatment → IRS2 levels in gingival biopsies
Non-surgical periodontal treatment → IRS2 mRNA levels in peripheral blood mononuclear cells
Non-surgical periodontal treatment → IRS2 mRNA levels in peripheral blood mononuclear cells
Non-surgical periodontal treatment → Salivary SOD enzymatic activity
Non-surgical periodontal treatment → Salivary SOD enzymatic activity
Non-surgical periodontal treatment → Superoxide Dismutase (SOD)
Non-surgical periodontal treatment → Superoxide Dismutase (SOD)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Non-surgical periodontal treatment and IRS2 levels in gingival biopsies, Non-surgical periodontal treatment and IRS2 mRNA levels in peripheral blood mononuclear cells.
This study contributes to the evidence on the following intervention-outcome relationships.
Procedures
Curated evidence collections and hubs this study is part of.
All studies measuring IRS2 levels in gingival biopsies
Measures IRS2 levels in gingival biopsies as a key outcome.
All studies measuring IRS2 mRNA levels in peripheral blood mononuclear cells
Measures IRS2 mRNA levels in peripheral blood mononuclear cells as a key outcome.
All studies on Non-surgical periodontal treatment
Contributes to Non-surgical periodontal treatment evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Non-surgical periodontal treatment appears to improve IRS2 levels in gingival biopsies.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
IRS2 levels in gingival biopsies
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment appears to improve IRS2 mRNA levels in peripheral blood mononuclear cells.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
IRS2 mRNA levels in peripheral blood mononuclear cells
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment appears to improve Superoxide Dismutase (SOD).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Superoxide Dismutase (SOD)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Non-surgical periodontal treatment for Salivary SOD enzymatic activity.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Salivary SOD enzymatic activity
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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