Last updated July 22, 2026
Key finding
The difference between HbA1c values at baseline (Mdn = 7.7) and 6 months after non-surgical periodontal treatment (Mdn = 7.2) was statistically significant.
This study investigated the impact of non-surgical periodontal treatment on glycemic control and systemic inflammation in patients with Type 2 Diabetes, finding significant improvements in HbA1c and CRP levels at 6 months.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the impact of non-surgical periodontal treatment on glycemic control and systemic inflammation in patients with Type 2 Diabetes, finding significant improvements in HbA1c and CRP levels at 6 months.
These findings highlight the importance of periodontal health in managing Type 2 Diabetes. Improved glycemic control and reduced inflammation can lead to better overall health outcomes, potentially reducing complications associated with diabetes.
The study's sample size and demographic diversity were not specified. Results may not be generalizable to all populations with Type 2 Diabetes. Short follow-up duration limits long-term effectiveness assessment.
Published in
Publication details and source links for this paper.
Biagio R, Elisabetta F, Massimo C, et al. The Role of Periodontal Therapy in Glycemic Control and Systemic Inflammation in Patients with Type 2 Diabetes. International Journal of Environmental Research and Public Health. 2021;18(6):3018. doi:10.3390/ijerph18063018
HbA1c decreased significantly from a median of 7.7 to 7.2 after 6 months (p = 0.012).
C-reactive protein levels were significantly lower in the intervention group at 6 months (p = 0).
No significant change in HbA1c was observed at 3 months (p = 0.075).
CRP levels showed no significant change between 3 and 6 months (p = 0.092).
Evidence network
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This study contributes evidence to Non-surgical periodontal treatment and C-reactive protein, HbA1c.
This study contributes evidence to
Primary intervention
Non-surgical periodontal treatment
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
2
Evidence pairs
368
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Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Non-surgical periodontal treatment → C-reactive protein
Non-surgical periodontal treatment → C-reactive protein
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Non-surgical periodontal treatment and HbA1c, Non-surgical periodontal treatment and Inflammatory Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Non-surgical periodontal treatment
Contributes to Non-surgical periodontal treatment evidence base.
All studies measuring Inflammatory Markers
Measures Inflammatory Markers as a key outcome.
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10 results
5 results
10 results
10 results
5 results
Generated from the study's connected evidence using Evidence Intelligence™.
Non-surgical periodontal treatment may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 83.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Non-surgical periodontal treatment may improve C-reactive protein.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Strong | EvidenceScore™ 81.1 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
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