Last updated August 16, 2026
Key finding
IL-6 levels decreased significantly from baseline (152.54 ± 1.46 pg/µL) to 30 days (117.49 ± 1.50 pg/µL) after SRP (p=0.000).
This study investigated the impact of Scaling and Root Planing (SRP) on salivary IL-6 levels in chronic periodontitis patients with Type 2 diabetes, finding significant reductions in IL-6 and other periodontal measures.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the impact of Scaling and Root Planing (SRP) on salivary IL-6 levels in chronic periodontitis patients with Type 2 diabetes, finding significant reductions in IL-6 and other periodontal measures.
These findings highlight the importance of periodontal treatment in patients with Type 2 diabetes, as managing gum disease may also help reduce systemic inflammation indicated by lower IL-6 levels. This could lead to better overall health outcomes for diabetic patients.
The study did not assess long-term effects beyond 30 days. Sample size and demographic diversity may limit generalizability. Potential confounding factors were not fully controlled.
Published in
Publication details and source links for this paper.
Alexander M, John RA, Sanghamitra G, et al. The Effect of Scaling and Root Planing on Salivary IL-6 Levels in Chronic Periodontitis Patients with Type 2 Diabetes. Cureus. 2023;15(9):e45388. doi:10.7759/cureus.45388
Salivary IL-6 levels decreased significantly from 152.54 ± 1.46 pg/µL to 117.49 ± 1.50 pg/µL (p=0.000).
Plaque Index decreased from 3.77 ± 0.41 to 1.95 ± 0.36 (p=0.000).
Gingival Index decreased from 1.66 ± 0.19 to 0.35 ± 0.08 (p=0.000).
Evidence network
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This study contributes evidence to Scaling and root planing only and Change in Bleeding Index from Baseline to 8 Weeks, Gingival Index (GI), Interleukin-6 (IL-6), and 3 more.
This study contributes evidence to
Primary intervention
Scaling and root planing only
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
6
Evidence pairs
59
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Contributes evidence
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Primary evidence
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Intervention
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Core evidence
The primary outcomes reported in this study.
Scaling and root planing only → Change in Bleeding Index from Baseline to 8 Weeks
Scaling and root planing only → Change in Bleeding Index from Baseline to 8 Weeks
Scaling and root planing only → Gingival Index (GI)
Scaling and root planing only → Gingival Index (GI)
Scaling and root planing only → Interleukin-6 (IL-6)
Scaling and root planing only → Interleukin-6 (IL-6)
Scaling and root planing only → Periodontal probing depth
Scaling and root planing only → Periodontal probing depth
Scaling and root planing only → Plaque Index (PI)
Scaling and root planing only → Plaque Index (PI)
Scaling and root planing only → Relative attachment level
Scaling and root planing only → Relative attachment level
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Scaling and Root Planing Procedures and Gingival Index (GI), Scaling and Root Planing Procedures and Periodontal probing depth.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Gingival Index (GI)
Measures Gingival Index (GI) as a key outcome.
All studies measuring Periodontal probing depth
Measures Periodontal probing depth as a key outcome.
All studies on Scaling and Root Planing Procedures
Contributes to Scaling and Root Planing Procedures evidence base.
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3 results
3 results
3 results
3 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Scaling and Root Planing Procedures appears to improve Inflammatory Markers.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Interleukin-6 (IL-6)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Scaling and root planing only may improve Gingival Index (GI).
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Gingival Index (GI)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Scaling and root planing only appears to improve Periodontal probing depth.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Periodontal probing depth
EvidenceScore™ Strong | EvidenceScore™ 78.6 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Scaling and root planing only appears to improve Plaque Index (PI).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Plaque Index (PI)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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