Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Weight management improves metabolomic profiles in type 2 diabetes
Last updated August 22, 2026
Key finding
Decreases in branched-chain amino acids were associated with the intervention (Holm-corrected p <0.05).
This study evaluated the metabolomic effects of a weight management program in individuals with type 2 diabetes, finding significant changes in various metabolites.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the metabolomic effects of a weight management program in individuals with type 2 diabetes, finding significant changes in various metabolites.
Clinical relevance
These findings highlight the potential of lifestyle interventions in managing type 2 diabetes and improving metabolic health. By effectively reducing harmful metabolites and enhancing beneficial ones, such programs may contribute to diabetes remission and overall better health outcomes for patients.
Keep in mind
Unclear effectiveness of some outcomes Potential limitations in generalizability due to specific population characteristics Limited sample size may affect the robustness of findings
Published in
Journal Reference
Publication details and source links for this paper.
Laura JC, David AH, Caroline JB, et al. Metabolomic effects of a weight management programme in individuals with type 2 diabetes: a randomized controlled trial. Diabetologia. 2023;67(1):74-87. doi:10.1007/s00125-023-06019-x
Main Effects
Decreased branched-chain amino acids by -0.82 mmol/L (p=0.001)
Decreased sugars by -0.75 mmol/L (p=0.001)
Decreased LDL triglycerides by -0.67 mmol/L (p=0.001)
Increased sphingolipids by 0.59 mmol/L (p=0.001)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Weight management programme and Blood glucose, Decreases in branched-chain amino acids, Decreases in sugars, and 6 more.
This study contributes evidence to
Primary intervention
Weight management programme
Primary outcomes
- Blood glucose
- Decreases in branched-chain amino acids
- Decreases in sugars
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
9
Evidence pairs
9
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 64
2
Related topics
9
Evidence pairs
886
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 9 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Fasting Blood Glucose
matched_outcome
Related evidence
Evidence topic
Glycemic Control
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Decreases in branched-chain amino acids
Weight management programme → Decreases in branched-chain amino acids
Weight management programme → Decreases in branched-chain amino acids
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerDecreases in sugars
Weight management programme → Decreases in sugars
Weight management programme → Decreases in sugars
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerIncreases in metabolites related to fatty acid metabolism
Weight management programme → Increases in metabolites related to fatty acid metabolism
Weight management programme → Increases in metabolites related to fatty acid metabolism
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerIncreases in plasmalogens associated with weight management intervention
Weight management programme → Increases in plasmalogens associated with weight management intervention
Weight management programme → Increases in plasmalogens associated with weight management intervention
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerReduction in Fructose Levels
Weight management programme → Reduction in Fructose Levels
Weight management programme → Reduction in Fructose Levels
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerReduction in Mannose Levels
Weight management programme → Reduction in Mannose Levels
Weight management programme → Reduction in Mannose Levels
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
Build your evidence library
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Evidence Suggest
- Significant decreases in branched-chain amino acids and sugars linked to the intervention.
- Greater reductions in glucose and fructose among those achieving diabetes remission.
- Increases in beneficial metabolites like sphingolipids and plasmalogens.
Who this applies to
- Adults diagnosed with type 2 diabetes
- Individuals seeking weight management solutions
Keep in Mind
- Results may not be generalizable to all populations with diabetes.
- Further research needed to confirm long-term effects.
- Effectiveness of the intervention may vary based on individual adherence.
Between the Lines
- Unclear effectiveness of some outcomes
- Potential limitations in generalizability due to specific population characteristics
- Limited sample size may affect the robustness of findings
Evidence Library
Build your evidence library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Weight management programme and Fasting Glucose, Weight management programme and Decreases in branched-chain amino acids.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Weight management programme → Fasting Glucose
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceBehavioral & Lifestyle
Weight management programme → Decreases in branched-chain amino acids
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceBehavioral & Lifestyle
Weight management programme → Sphingolipids
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Decreases in branched-chain amino acids Evidence Hub
All studies measuring Decreases in branched-chain amino acids
1 studies
outcome_hubMeasures Decreases in branched-chain amino acids as a key outcome.
Fasting Glucose Evidence Hub
All studies measuring Fasting Glucose
1 studies
outcome_hubMeasures Fasting Glucose as a key outcome.
Sphingolipids Evidence Hub
All studies measuring Sphingolipids
1 studies
outcome_hubMeasures Sphingolipids as a key outcome.
Weight management programme Evidence Hub
All studies on Weight management programme
1 studies
intervention_hubContributes to Weight management programme evidence base.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Weight management programme and Blood glucose
Intervention: Weight management programmeOutcome: Blood glucose
1 results
All studies on Weight management programme and Decreases in branched-chain amino acids
Intervention: Weight management programmeOutcome: Decreases in branched-chain amino acids
1 results
All studies on Weight management programme
Intervention: Weight management programme
1 results
All studies measuring Blood glucose
Outcome: Blood glucose
1 results
All studies measuring Decreases in branched-chain amino acids
Outcome: Decreases in branched-chain amino acids
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Weight management programme improve blood glucose?
Emerging Evidence
Weight management programme appears to improve blood glucose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Blood glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Weight management programme improve decreases in branched-chain amino acids?
Emerging Evidence
Weight management programme appears to improve decreases in branched-chain amino acids.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Decreases in branched-chain amino acids
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Weight management programme improve decreases in sugars?
Emerging Evidence
Weight management programme appears to improve decreases in sugars.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Decreases in sugars
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Weight management programme improve increases in metabolites related to fatty acid metabolism?
Emerging Evidence
Weight management programme appears to improve increases in metabolites related to fatty acid metabolism.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Increases in metabolites related to fatty acid metabolism
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Next steps
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Evidence topics
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All studies on Weight management programme and Decreases in branched-chain amino acidsAll studies on Weight management programme and Decreases in sugarsAll studies on Weight management programme and Increases in metabolites related to fatty acid metabolismAll studies on Weight management programme and Increases in plasmalogens associated with weight management intervention
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